Dr. Brendan Kennedy pictured in HKPB Scientific\'s laboratory facilities at the Universisty of Limerick with the members of the Science Advisory Board of HKPB Scientific: Dr. Tewfik Soulimane, Prof. Tony Pembroke and Dr. Seamus McMonagle of the Materials and Surface Science Institute, University of Limerick.
Academic Interaction
Academic interaction is a key factor in determining the success of small research companies in the bio-medical field. In this regard HKPB Scientific is fortunate to have as Scientific Advisors, three experts in the fields on which the company’s research efforts are focused of the calibre of Dr. Seamus McMonagle, Dr. Tewfik Soulimane and Prof. Tony Pembroke. All three have long and distinguished records of publication in their respective fields. Presently Dr. McMonagle and Prof. Pembroke are collaborating with HKPB Scientific on research projects supported by Enterprise Ireland focused on developing the proprietary technology of HKPB Scientific.
A Selection of Recent Papers by HKPB’s Science Advisory Board
“Structure and stability of hydroxyapatite: Density functional calculation and Rietveld analysis”, Haverty, D., Tofail, S.A.M., Stanton, K.T., and Mc Monagle, J.B., Physical Review B, 71, (9), 094103, 2005.
“Structural Order and Dielectric Behaviour of Hydroxyapatite”, Tofail, S. A. M., Haverty, D., Stanton, K. T., and McMonagle, J. B., Ferroelectrics, 319, 117-123, 2005.
“Surface Characterisation of Electrografted Random Poly[Carbazole-Co-3-Methylthiophene] Copolymers on Carbon Fiber: XPS, AFM and Raman Spectroscoopy”, Sarac, A.S., Tofail, S.A.M., Serantoni, M., Henry, J., Cunnane, V.J., and McMonagle, J.B., Applied Surface Science, 222, 148-165, 2004.
“Calorimetric Combustible Gas Sensor Based on a Planar Thermopile Array: Fabrication, Characterisation, and Gas Response”, V. Casey, J. Cleary, G. D’Arcy, J.B. Mc Monagle, Sensors and Actuators B, 96, 114-123, 2003.
“Mass Transfer Effects in the Oxidation of Aqueous Organic Compounds over a Hydrophobic Solid Catalyst”, Lavelle, K., and J.B. Mc Monagle, Chemical Engineering Science, 56, 5091-5102, 2001.
Roberts, A.P., M., Chandler , P., Courvalin , P., Guedon, G., Mullany, M, Osborn, J.T Pembroke, J. I. Rood, J.Smith, M., Tsuda and D.E., Berg (2008) Revised nomenclature for transposable genetic elements. PLASMID 60:167-173
O’Halloran, J.A., B. M., McGrath and J. T., Pembroke (2007) The orf4 gene of the enterobacterial ICE, R391, encodes a novel UV inducible recombinational directionality factor, Jef, involved in excision and transfer of the ICE. FEMS MICROBIOLOGY LETTERS 272: 99-105
Pembroke, J.T., and A.V.Piterina (2006) A novel ICE in the genome of Shewanella putrefaciens W3-18-1: Comparison with the SXT/R391 ICE-like elements. FEMS MICROBIOLOGY LETTERS 264 (1) 80-88.
McGrath B.M., O’Halloran, J.A. Piterina, A and J. T. Pembroke (2006) Molecular probes to detect IncJ elements: a family of integrating, antibiotic resistance mobile genetic elements. Journal of Microbiological Methods 66 (1) (Accepted and in Press)
Pembroke, J.T., and McGrath, B.M., and J.A. O’Halloran (2005) Environmental control of antibiotic resistance spread: transfer of R391 an integrating bacterial mobile, drug resistant genetic element is inducible. National Institute of Health Sciences Research Bulletin 3(2) 37-39.
Pembroke, J.T., and B.M., McGrath (2005) Inverse PCR to localise insertion sites of integrating mobile elements: location of the insertion site of the bacterial genomic island R391. The PCR Encyclopaedia http://www.pcr-encyclopedia.com/inverse-pcr-genomic-island-insertion-site-determination-r391-1833.html Horizon Press
A. Giuffre, G. Stubauer, P. Sarti, M. Brunori, W. Zumft, G. Buse and T. Soulimane (1999) NO Kinetic properties of the ba3-oxidase from Thermus thermophilus. PNAS 96, 14718-14723.T. Soulimane, G. Buse, G. P. Bourenkov, H. D. Bartunik, R. Huber and M.E. Than (2000) Structure and Mechanism of the ba3-Cytochrome c Oxidase from Thermus thermophilus. EMBO J. 19, 1766-1776.
R. Kiefersauer, M. E. Than, H. Dobbek, L. Gremer, M. Melero, S. Strobl, J. M. Dias,
T. Soulimane and R. Huber (2000) A novel free-mounting system for protein crystals: transformation and improvement of diffraction power by accurately controlled humidity changes. J. Appl. Cryst. 33, 1223-1230.
S. Macedo-Ribeiro, B. Martins, P.J.B. Pereira, R. Huber, G. Buse and T. Soulimane (2001) Thermostability of bacterial ferredoxins: Crystal structure of the ferredoxin from Thermus thermophilus at 1.64 A resolution. J. Biol. Inorg. Chem. 6, 663-674.
K. Koutsoupakis, T. Soulimane and C. Varotsis (2003) Ligand binding in a docking site of cytochrome c oxidase: A Time-Resolved Step-Scan Fourier Transform Infrared Study JACS 125, 14728-14732.
P. Nicholls and T. Soulimane (2004) The mixed valence state of the oxidase binuclear centre: how Thermus thermophilus cytochrome ba3 differs from classical aa3 in the aerobic steady state and when inhibited by cyanide. BBA 1655, 381-387.
D. Mooser, O. Maneg, C. Corvey, T. Steiner, F. Malatesta, M. Karas, T. Soulimane and B. Ludwig (2005) A four-subunit cytochrome bc1 complex complements the respiratory chain of Thermus thermophilus. BBA 1708, 262-274
T. Ohta, E. Pinakoulaki, T. Soulimane, T. Kitagawa, C. Varotsis (2005) Detection of the primary ferrous nitrosyl heme,Fe2+-NO intermediate in the reduction of NO to N20 by cytochrome ba3 oxidase from Thermus thermophilus. JACS 127, 15161-15167.
C. Varotsis, T. Ohta, T. Kitagawa, T. Soulimane and E. Pinakoulaki (2007) The structure of the hyponitrite species in the heme Fe-CuB center of ba3 oxidase from Thermus thermophilus. Angw. Chem. Int. Ed. Engl. 46, 2210-2214.